Cushing's disease is caused by hyperadrenocorticism. Equine Cushing's disease results from functional adenomas or adenomatous hyperplasia of the pituitary (pars intermedia). Some reports indicate that the average age of affected horses is around 19 years. These animals often suffer from haircoat abnormlities (hirsutism). In TCM, Cushing's disease is often considered to be one of Xiao-ke diseases, especially Xia-xiao. There are often three Patterns: Yin Deficiency, Qi-yin Deficiency and Yang Deficiency. With age, the Kidney Yin and Yang falls. The first stage of Cushing's disease can be Kidney Yin Deficiency which can cause Kidney Qi Deficiency and subsequently lead to Kidney Qi-Yin Deficiency. Kidney Yang Deficiency may be the last stage of Cushing's disease. Ophiopogon Powder (A3510), Rehmannia 11 (A2194) and Rehmannia 14 (A0150) are used for Kidney Yin Deficiency, Kidney Qi-Yin Deficiency, and Kidney Yang Deficiency respectively. Clinical observations indicate that Rehmannia 14 is very effective for treating Cushing's disease due to Kidney Yang Deficiency in horses and dogs.

Western Medical Indications:
Cushing's disease
Diabetes
Equine metabolic syndrome
Hyperthyroidism

TCVM Indications:
Chronic/recurrent laminitis
Hirsutism
Kidney Yang Deficiency
Polyuria and polydipsia
Pulse: Deep and weak
Tongue: Pale, purple and wet

Contraindications:
Do not use during pregnancy

Warning:
May cause drug testing to be positive

Dosage for Horse:
15 g twice daily as top dressing on feed

Dosage for Dog/Cat:
0.5 g per 10 to 20 lb body weight twice daily

Directions:
Use as needed up to 3 months

Chinese Principles of Treatment:
Nourish Yin, tonify Qi and Yang

Classical Antecedent:
Jin Gui Shen Qi Wan from Jin Gui Yao Lue Fang Lun (Synopsis of Prescriptions from the Golden Cabinet) written by Zhang Zhong-Jing in 220 AD.

Ingredients:
Bai Shao-Paeonia, Fu Ling-Poria, Fu Zi-Aconite, Gui Zhi-Cinnamomum, Huang Bai-Phellodendron, Huang Qi-Astragalus,
Mai Men Dong-Ophiopogon, Mu Dan Pi-Moutan, Shan Yao-Dioscorea, Shan Zhu Yu-Cornus, Sheng Di Huang-Rehmannia,
Wu Wei Zi-Schisandra, Ze Xie-Alisma, Zhi Mu-Anemarrhena